AKT1 polymorphisms are associated with tuberculosis in the Chinese population
Identifieur interne : 000111 ( Psycho/Analysis ); précédent : 000110; suivant : 000112AKT1 polymorphisms are associated with tuberculosis in the Chinese population
Auteurs : X. Wang [République populaire de Chine] ; Z. Cao [République populaire de Chine] ; J. Jiang [République populaire de Chine] ; Y. Zhu [République populaire de Chine] ; M. Dong [République populaire de Chine] ; A. Tong [République populaire de Chine] ; X. Cheng [République populaire de Chine]Source :
- International Journal of Immunogenetics [ 1744-3121 ] ; 2010-04.
English descriptors
- Teeft :
- Akt1, Akt1 gene, Akt1 genomic sequence, Akt1 inhibitors, Akt1 locus, Akt1 polymorphisms, Akt1 snps, Allele, Allele frequencies, Association analysis, Association study, Biological psychiatry, Blackwell publishing, Body mass index, Chinese patients, Chinese population, Control individuals, Critical role, Ethnic group, Fujita health university school, Genotype, Haplotype, Heterozygous genotype, Homozygous genotype, Host cell, Host cells, Human cancer cells, Infectious diseases, International journal, Intracellular growth, Kinase, Mycobacterium tuberculosis, Myxoma virus, Nadao iwata, National academy, Neuroscience letters, Pathway, Patient group, Persistent infection, Phagosome maturation, Pi3k, Polymorphism, Previous study, Protein kinase, Serine threonine kinase, Single nucleotide polymorphisms, Snp, Statistical analysis, Statistical package spss, Susceptibility, Unphased program, Whole blood.
Abstract
AKT1, a serine/threonine kinase, plays a critical role in the controlling of intracellular growth of Mycobacterium tuberculosis. In this study, we investigated whether polymorphisms in AKT1 affect susceptibility to tuberculosis (TB). Two single nucleotide polymorphisms of AKT1, IVS3+18C>T and +726G>A were genotyped in Chinese patients with pulmonary TB by polymerase chain reaction‐restriction fragment length polymorphism. Patients with pulmonary TB had significantly lower IVS3+18 C/C genotype and higher C/T genotype compared with age‐, gender‐ and ethnically matched controls (P < 0.05). The T–A haplotype frequency was significantly higher in patients than in controls (P < 0.05). In conclusion, our result indicates that AKT1 polymorphisms are associated with susceptibility to pulmonary TB.
Url:
DOI: 10.1111/j.1744-313X.2010.00897.x
Affiliations:
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Dong</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Laboratory Medicine, Institute of Tuberculosis, 309 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tong, A" sort="Tong, A" uniqKey="Tong A" first="A." last="Tong">A. Tong</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Laboratory Medicine, Institute of Tuberculosis, 309 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cheng, X" sort="Cheng, X" uniqKey="Cheng X" first="X." last="Cheng">X. Cheng</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Division of Research, Institute of Tuberculosis, 309 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Immunogenetics</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF IMMUNOGENETICS</title><idno type="ISSN">1744-3121</idno><idno type="eISSN">1744-313X</idno><imprint><biblScope unit="vol">37</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="97">97</biblScope><biblScope unit="page" to="101">101</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-04">2010-04</date></imprint><idno type="ISSN">1744-3121</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1744-3121</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Akt1</term><term>Akt1 gene</term><term>Akt1 genomic sequence</term><term>Akt1 inhibitors</term><term>Akt1 locus</term><term>Akt1 polymorphisms</term><term>Akt1 snps</term><term>Allele</term><term>Allele frequencies</term><term>Association analysis</term><term>Association study</term><term>Biological psychiatry</term><term>Blackwell publishing</term><term>Body mass index</term><term>Chinese patients</term><term>Chinese population</term><term>Control individuals</term><term>Critical role</term><term>Ethnic group</term><term>Fujita health university school</term><term>Genotype</term><term>Haplotype</term><term>Heterozygous genotype</term><term>Homozygous genotype</term><term>Host cell</term><term>Host cells</term><term>Human cancer cells</term><term>Infectious diseases</term><term>International journal</term><term>Intracellular growth</term><term>Kinase</term><term>Mycobacterium tuberculosis</term><term>Myxoma virus</term><term>Nadao iwata</term><term>National academy</term><term>Neuroscience letters</term><term>Pathway</term><term>Patient group</term><term>Persistent infection</term><term>Phagosome maturation</term><term>Pi3k</term><term>Polymorphism</term><term>Previous study</term><term>Protein kinase</term><term>Serine threonine kinase</term><term>Single nucleotide polymorphisms</term><term>Snp</term><term>Statistical analysis</term><term>Statistical package spss</term><term>Susceptibility</term><term>Unphased program</term><term>Whole blood</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">AKT1, a serine/threonine kinase, plays a critical role in the controlling of intracellular growth of Mycobacterium tuberculosis. In this study, we investigated whether polymorphisms in AKT1 affect susceptibility to tuberculosis (TB). Two single nucleotide polymorphisms of AKT1, IVS3+18C>T and +726G>A were genotyped in Chinese patients with pulmonary TB by polymerase chain reaction‐restriction fragment length polymorphism. Patients with pulmonary TB had significantly lower IVS3+18 C/C genotype and higher C/T genotype compared with age‐, gender‐ and ethnically matched controls (P < 0.05). The T–A haplotype frequency was significantly higher in patients than in controls (P < 0.05). In conclusion, our result indicates that AKT1 polymorphisms are associated with susceptibility to pulmonary TB.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X." last="Wang">X. Wang</name></noRegion><name sortKey="Cao, Z" sort="Cao, Z" uniqKey="Cao Z" first="Z." last="Cao">Z. Cao</name><name sortKey="Cheng, X" sort="Cheng, X" uniqKey="Cheng X" first="X." last="Cheng">X. Cheng</name><name sortKey="Dong, M" sort="Dong, M" uniqKey="Dong M" first="M." last="Dong">M. Dong</name><name sortKey="Jiang, J" sort="Jiang, J" uniqKey="Jiang J" first="J." last="Jiang">J. Jiang</name><name sortKey="Tong, A" sort="Tong, A" uniqKey="Tong A" first="A." last="Tong">A. Tong</name><name sortKey="Zhu, Y" sort="Zhu, Y" uniqKey="Zhu Y" first="Y." last="Zhu">Y. Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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